The effect of statins on rate of cognitive decline in mild cognitive impairment

OBJECTIVE This study's aims are to identify whether or not a relationship between statin use and rate of cognitive decline exists. BACKGROUND The relationship between statins and MCI has been investigated in the past with the evidence showing mixed results. METHODS 768 subjects were identified with MCI. Subjects were stratified into 6 possible groups according to ApoE4 status and statin use and assessed for decline in cognitive function. RESULTS All cognitive assessments trended towards less decline with statin use. ADAS11 showed the biggest difference in mean change between statin users and nonusers (-0.82 vs. -1.22 respectively). Change reached marginal significance on the ADAS11 when stratified by ApoE4 negative subjects. CONCLUSION All cognitive assessments trended towards less decline when subjects were concurrently treated with a statin, supporting the position that statins do not have a net negative effect on cognitive assessment and suggests a potential treatment benefit.